PEER-REVIEWED PUBLICATIONS
44. Arakawa, H., Arakawa, K. & Deak, T. (2009). Acute illness induces the release of aversive odor cues from adult, but not prepubertal, male rats and suppresses social investigation by conspecifics. Behavioral Neuroscience, in press.
43. Hennessy, M.B., Deak, T. & Schiml-Webb, P.A. (2009). Early attachment-figure separation and increased risk for later depression: Potential mediation by proinflammatory processes. Neuroscience & Biobehavioral Reviews, in press.
42. Blandino Jr., P, Barnum, CJ, Solomon, LG, Larish, Y, Lankow, BS & Deak, T. (2009). Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress. Brain, Behavior & Immunity, 23, 958-968. (PDF)
41. Hennessy, M.B., Schiml-Webb, P.A. & Deak, T. (2009). Separation, sickness, and depression: A new perspective on an old animal model. Current Directions in Psychological Science, 18(4), 227-231. (PDF)
40. Schiml-Webb, P.A., Miller, E., Deak, T. & Hennessy, M.B. (2009) Alpha-melanocyte stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups. Developmental Psychobiology, 51(5), 399-407. (PDF)
39. Arakawa, H., Blandino Jr., P. & Deak, T. (2009). Central infusion of Interleukin-1 receptor antagonist blocked the reduction in social investigation produced by prior stressor exposure. Physiology & Behavior, 98, 139-146. (PDF)
38. Perkeybile, A.M., Schiml-Webb, P.A., O’Brien, E., Deak, T. & Hennessy, M.B. (2009). Anti-inflammatory influences on behavioral, but not cortisol, responses during maternal separation. Psychoneuroendocrinology, 34(7), 1101-1108. (PDF)
37. Bishop, C., Krolewski, D.M., Eskow, K.L., Barnum, C.J., Dupre, K.B., Deak, T. & Walker P.D. (2009). Role of the striatum in the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rat. Journal of Neuroscience Research, 87(7), 1645-1658. (PDF)
36. Deak, T., Arakawa, H., Bekkedal, M.Y.V. & Panksepp, J. (2009). Validation of a novel social investigation task that may dissociate social motivation from exploratory activity. Behavioural Brain Research, 199, 326-333. (PDF)
35. Barnum, C.J., Eskow, K.L., Dupre, K., Blandino Jr., P., Deak, T. & Bishop, C. (2008). Exogenous corticosterone reduces L-DOPA-induced dyskinesia in the hemi-Parkinsonian rat: role for interleukin-1b. Neuroscience, 156, 30-41. (PDF)
34. Barnum, C.J., Blandino Jr., P. & Deak, T. (2008). Social status modulates basal IL-1 concentrations in the hypothalamus of pair-housed rats and influences certain features of stress reactivity. Brain, Behavior & Immunity, 22, 517-527. (PDF)
33. Deak, T. (2007). From classic aspects of the stress response to neuroinflammation and sickness: implications for individuals and offspring of diverse species. International Journal of Comparative Psychology, 20, 96-110. (PDF)
32. Wright, A.J., Aguilar Soto, N., Baldwin, A.L., Bateson, M., Beale, C., Clark, C., Deak, T., Edwards, E.F., Fernandez Rodriguez, A., Godinho, A., Hatch, L., Kakuschke, A., Lusseau, D., Martineau, D., Romero, L.M., Weilgart, L., Wintle, B., Notarbartolo di Sciara, G. & Martin, V. (2007). Anthropogenic noise as a stressor in animals: a multidisciplinary perspective. International Journal of Comparative Psychology, 20, 250-273. (PDF)
31. Wright, A.J., Aguilar Soto, N., Baldwin, A.L., Bateson, M., Beale, C., Clark, C., Deak, T., Edwards, E.F., Fernandez Rodriguez, A., Godinho, A., Hatch, L., Kakuschke, A., Lusseau, D., Martineau, D., Romero, L.M., Weilgart, L., Wintle, B., Notarbartolo di Sciara, G. & Martin, V. (2007). Do marine mammals experience stress related to anthropogenic noise? International Journal of Comparative Psychology, 20, 274-316. (PDF)
30. Barnum, C.J., Blandino Jr., P. & Deak, T. (2007). Adaptation of corticosterone and hyperthermic responses to stress following repeated stressor exposure. Journal of Neuroendocrinology, 19(8), 632-642. (PDF)
29. Hennessy, M.B., Schiml-Webb, P.A., & Deak, T. (2007). -MSH and indomethacin attenuate the passive responses of guinea pig pups: evidence for stress-induced sickness during isolation, Psychoneuroendocrinology, 32(5), 508-515. (PDF)
28. Blandino Jr., P., Barnum, C.J. & Deak, T. (2006). The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1b responses to stress. Journal of Neuroimmunology, 173, 87-95. (PDF)
27. Deak, T. & Panksepp, J. (2006). Play behavior in rats pretreated with scopolamine: increased play solicitation by the non-injected partner. Physiology & Behavior, 87(1), 120-125. (PDF)
26. Schiml-Webb, P.A., Deak, T., Greenlee, T.M., Maken, D. & Hennessy, M.B. (2006). Alpha melanocyte stimulating hormone reverses postulated stress-induced sickness behaviors in isolated guinea pig pups. Behavioural Brain Research, 168(2), 326-330. (PDF)
25. Deak, T., Bellamy, C. & Bordner, K.A. (2005). Protracted increases in core body temperature and interleukin-1 following acute administration of lipopolysaccharide: implications for the stress response. Physiology & Behavior, 85(3), 296-307. (PDF)
24. Deak, T., Bellamy, C., D’Agostino, L.G., Rosanoff, M., McElderry, N.K. & Bordner, K.A. (2005). Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide. Behavioural Brain Research, 160, 125-134. (PDF)
23. Der-Avakian, A., Will, M.J., Bland, S.T., Deak, T., Nguyen, K.T., Schmid, M.J., Spencer, R.L.Watkins, L.R. & Maier, S.F. (2005). Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats. Psychopharmacology, 179, 409-417. (PDF)
22. Deak, T., Bordner, K.A., McElderry, N.K., Barnum, C.J. & Blandino, P., Deak, M.M. & Tammariello, S.P. (2005). Stress-induced increases in hypothalamic IL-1: a systematic comparison of multiple stressor paradigms. Brain Research Bulletin, 64(6), 541-556. (PDF)
21. Hennessy, M.B., Deak, T., Schiml-Webb, P., Wilson, S.E., Greenlee, T.M. & McCall, E. (2004). Behavior of guinea pig pups during isolation in a novel environment may represent stress-induced sickness behaviors. Physiology & Behavior, 81, 5-13. (PDF)
20. Deak, T., Bellamy, C. & D’Agostino, L. (2003). Exposure to forced swim stress does not alter central production of IL-1. Brain Research, 972, 53-63. (PDF)
19. Grahn, R.E., Hammack, S.E., Will, M.J., O’Connor, K.A., Deak, T., Sparks, P.D., Watkins, L.R. & Maier, S.F. (2002). Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats. Behavioural Brain Research, 134, 387-392. (PDF)
18. Johnson, J.D., O’Connor, K.A., Deak, T., Stark, M., Watkins, L.R. & Maier, S.F. (2002). Prior stressor exposure sensitizes LPS-induced cytokine production. Brain, Behavior, & Immunity, 16, 461-476. (PDF)
17. Fleshner, M., Campisi, J., Deak, T., Greenwood, B.N., Kintzel, J.A., Leem, T.H., Smith, T.P. & Sorensen, B. (2002). Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats. American Journal of Physiology, 282, R1680-R1686. (PDF)
16. Johnson, J.D., O'Connor, K.A., Deak, T., Spencer, R.L., Watkins, L.R. & Maier, S.F. (2002). Prior stressor exposure primes the HPA axis. Psychoneuroendocrinology, 27(3), 353-365. (PDF)
15. Hennessy, M.B., Deak, T. & Schiml-Webb, P.A. (2001). Stress-induced sickness behaviors: an alternative hypothesis for responses during maternal separation. Developmental Psychobiology, 39(2), 76-83. (PDF)
14. Fleshner, M., Deak, T., Nguyen, K.T., Watkins, L.R. & Maier, S.F. (2001). Endogenous glucocorticoids play a positive regulatory role in the anti-Keyhole Limpet Hemocyanin in vivo antibody response. Journal of Immunology, 166, 3813-3819. (PDF)
13. Moraska, A., Deak, T., Spencer, R.L., Roth, D. & Fleshner, M. (2000). Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats. American Journal of Physiology, 279(4), R1321-R1329. (PDF)
12. Spencer, R.L., Kalman, B.A., Cotter, C.S. & Deak T. (2000). Discrimination between changes in glucocorticoid receptor expression and activation in rat brain using western blot analysis. Brain Research, 868, 275-286. (PDF)
11. Nguyen, K.T., Deak, T., Will, M.J., Hunsaker, B.N., Fleshner, M., Watkins, L.R. & Maier, S.F. (2000). Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1 response to acute stress. Brain Research, 859, 193-201. (PDF)
10. Deak, T., Nguyen, K.T., Cotter, C.S., Fleshner, M., Watkins, L.R., Maier, S.F. & Spencer, R.L. (1999). Long term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor. Brain Research, 847, 211-220. (PDF)
9. Deak, T., Nguyen, K.T., Fleshner, M., Watkins, L.R. & Maier, S.F. (1999). Acute stress may facilitate recovery from a subcutaneous bacterial challenge. Neuroimmunomodulation, 6(5), 344-354. (PDF)
8. Deak, T., Nguyen, K.T., Ehrlich, A.L., Watkins, L.R., Spencer, R.L., Maier, S.F., Licinio J., Wong, M.-L., Chrousos, G.P., Webster, E. & Gold, P.W. (1999). The impact of the nonpeptide corticotropin-releasing hormone antagonist Antalarmin on behavioral and endocrine responses to stress. Endocrinology, 140(1), 79-86. (PDF)
7. Helmreich, D.L., Watkins, L.R., Deak, T., Maier, S.F., Akil, H. & Watson, S.J. (1999). The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology, 11, 121-128. (PDF)
6. Milligan, E.D., Nguyen, K.T., Deak, T., Hinde, J.L., Fleshner, M., Watkins, L.R. & Maier, S.F. (1998). The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Research, 810, 48-58. (PDF)
5. Nguyen, K.T., Deak, T., Owens, S.M., Kohno, T., Fleshner, M., Watkins, L.R., Maier, S.F. (1998). Exposure to acute stress induces brain interleukin-1 protein in the rat. Journal of Neuroscience, 18(6), 2239-2246. (PDF)
4. Deak, T., Meriwether, J.L., Fleshner, M., Spencer, R.L., Abouhamze, A., Moldawer, L.L., Grahn, R.E., Watkins, L.R. & Maier, S.F. (1997). Evidence that brief stress may induce the acute phase response in rats. American Journal of Physiology, 273(42), 1998-2004. (PDF)
3. Fleshner, M., Silbert, L., Deak, T., Goehler, L.E., Martin, D., Watkins, L.R. & Maier, S.F. (1997). TNF- induced corticosterone elevation but not serum protein or corticosterone binding globulin reduction is vagally mediated. Brain Research Bulletin, 44(6), 701-706. (PDF)
2. Galea, L.A.M., McEwen, B.S., Tanapat, P., Deak, T., Spencer, R.L. & Dhabhar, F.S. (1997). Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience, 81(3), 689-698. (PDF)
1. Fleshner, M., Deak, T., Spencer, R.L., Laudenslager, M.L., Watkins, L.R. & Maier, S.F. (1995). A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin following acute stressor exposure. Endocrinology, 136(12), 5336-5342. (PDF)
INVITED REVIEWS, COMMENTARIES & BOOK CHAPTERS
6. Deak, T. (2008). Immune cells and cytokine circuits: Toward a working model for understanding direct immune-to-adrenal communication pathways. Endocrinology, 149(4), 1433-1435. (PDF)
5. Deak, T. (2007). From hippocampus to dorsal horn: the pervasive impact of IL-1 on learning and memory spans the length of the neuroaxis. Brain, Behavior & Immunity, 21, 746-747. (PDF)
4. Hennessy, M.B., Schiml-Webb, P.A., Barnum, C.J. & Deak, T. (2007). Immune influences on behavior and endocrine responses during early development. In Czerbska, M.T. (Ed.). Psychoneuroendocrinology Research Trends. Nova Science Publishers, Inc. New York, NY, 293-320. (PDF)
3. Deak, T. & Larish, Y. (2006). Methods and motives for use of the forced swim test as an animal model of behavioral despair/depression. In Anderson, M.A. (Ed.). Tasks and techniques: A sampling of methodologies for the investigation of animal learning, behavior and cognition. Nova Science Publishers, Inc., 3-18. (PDF)
2. Deak, T. & Panksepp, J. (2004). Stress, sleep and sexuality in psychiatric disorders. In Panksepp, J. (Ed.), Textbook of Biological Psychiatry, Wiley-Liss, Inc. NY, 111-144. (PDF)
1. Maier, S.F., Nguyen, K.T., Deak, T., Milligan, E.D. & Watkins, L.R. (1999). Stress, learned helplessness, and brain interleukin-1b. In: R.Dantzer, B.B. Wollmann & R. Yirmiya (Eds.). Cytokines, stress, and depression. New York: Kluwer Academic/Plenum Publishers, 235-250. (PDF)